# Send Clarity Clinical to your agent Hand the extracted package to your coding agent with a concrete install brief instead of figuring it out manually. ## Fast path - Download the package from Yavira. - Extract it into a folder your agent can access. - Paste one of the prompts below and point your agent at the extracted folder. ## Suggested prompts ### New install ```text I downloaded a skill package from Yavira. Read SKILL.md from the extracted folder and install it by following the included instructions. Tell me what you changed and call out any manual steps you could not complete. ``` ### Upgrade existing ```text I downloaded an updated skill package from Yavira. Read SKILL.md from the extracted folder, compare it with my current installation, and upgrade it while preserving any custom configuration unless the package docs explicitly say otherwise. Summarize what changed and any follow-up checks I should run. ``` ## Machine-readable fields ```json { "schemaVersion": "1.0", "item": { "slug": "clarity-clinical", "name": "Clarity Clinical", "source": "tencent", "type": "skill", "category": "开发工具", "sourceUrl": "https://clawhub.ai/clarityprotocol/clarity-clinical", "canonicalUrl": "https://clawhub.ai/clarityprotocol/clarity-clinical", "targetPlatform": "OpenClaw" }, "install": { "downloadUrl": "/downloads/clarity-clinical", "sourceDownloadUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=clarity-clinical", "sourcePlatform": "tencent", "targetPlatform": "OpenClaw", "packageFormat": "ZIP package", "primaryDoc": "SKILL.md", "includedAssets": [ "SKILL.md", "scripts/api_client.py", "scripts/query_clinical.py" ], "downloadMode": "redirect", "sourceHealth": { "source": "tencent", "status": "healthy", "reason": "direct_download_ok", "recommendedAction": "download", "checkedAt": "2026-04-30T16:55:25.780Z", "expiresAt": "2026-05-07T16:55:25.780Z", "httpStatus": 200, "finalUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=network", "contentType": "application/zip", "probeMethod": "head", "details": { "probeUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=network", "contentDisposition": "attachment; filename=\"network-1.0.0.zip\"", "redirectLocation": null, "bodySnippet": null }, "scope": "source", "summary": "Source download looks usable.", "detail": "Yavira can redirect you to the upstream package for this source.", "primaryActionLabel": "Download for OpenClaw", "primaryActionHref": "/downloads/clarity-clinical" }, "validation": { "installChecklist": [ "Use the Yavira download entry.", "Review SKILL.md after the package is downloaded.", "Confirm the extracted package contains the expected setup assets." ], "postInstallChecks": [ "Confirm the extracted package includes the expected docs or setup files.", "Validate the skill or prompts are available in your target agent workspace.", "Capture any manual follow-up steps the agent could not complete." ] } }, "links": { "detailUrl": "https://openagent3.xyz/skills/clarity-clinical", "downloadUrl": "https://openagent3.xyz/downloads/clarity-clinical", "agentUrl": "https://openagent3.xyz/skills/clarity-clinical/agent", "manifestUrl": "https://openagent3.xyz/skills/clarity-clinical/agent.json", "briefUrl": "https://openagent3.xyz/skills/clarity-clinical/agent.md" } } ``` ## Documentation ### Clarity Clinical Skill Access clinical variant annotations from ClinVar and population frequency data from gnomAD through Clarity Protocol's integrated database. ### Quick Start List all clinical variants: python scripts/query_clinical.py Filter by gene symbol: python scripts/query_clinical.py --gene-symbol MAPT Get details for a specific variant: python scripts/query_clinical.py --gene MAPT --variant NM_005910.6:c.926C>T Get variant details in readable format: python scripts/query_clinical.py --gene MAPT --variant NM_005910.6:c.926C>T --format summary ### Clinical Variant Fields Each clinical variant includes: gene_symbol: HGNC gene symbol variant_notation: Full HGVS notation (transcript-based) clinvar_significance: Clinical significance classification (e.g., "Pathogenic", "Benign") clinvar_review_status: Review status stars (e.g., "criteria provided, multiple submitters") clinvar_last_evaluated: Date of last ClinVar evaluation gnomad_af: Allele frequency in gnomAD (population prevalence) gnomad_ac: Allele count in gnomAD gnomad_an: Total allele number in gnomAD fetched_at: When this data was retrieved from ClinVar/gnomAD ### ClinVar Significance Values Pathogenic: Strong evidence for disease causation Likely pathogenic: Moderate evidence for disease causation Benign: Strong evidence of no disease causation Likely benign: Moderate evidence of no disease causation Uncertain significance: Insufficient evidence Conflicting interpretations: Disagreement among submitters ### gnomAD Frequency Interpretation af < 0.0001: Very rare (< 0.01%) af < 0.001: Rare (< 0.1%) af < 0.01: Uncommon (< 1%) af >= 0.01: Common (>= 1%) ### Rate Limits Anonymous (no API key): 10 requests/minute With API key: 100 requests/minute To use an API key, set the CLARITY_API_KEY environment variable: export CLARITY_API_KEY=your_key_here python scripts/query_clinical.py --gene-symbol MAPT Get your API key at https://clarityprotocol.io ### Error Handling 404 Not Found: The specified gene/variant combination does not exist in the clinical database. 429 Rate Limit: You've exceeded the rate limit. The script will display how long to wait. 500 Server Error: The API server encountered an error. Try again later. Timeout: The request took longer than 30 seconds. ### Pagination Clinical variant lists are paginated. The API returns a next_cursor field if more results are available. ### Use Cases Check if a variant is pathogenic in ClinVar Get population frequency data for a mutation Compare clinical significance across variants in a gene Assess variant review status quality Filter common vs. rare variants using gnomAD ## Trust - Source: tencent - Verification: Indexed source record - Publisher: clarityprotocol - Version: 1.0.0 ## Source health - Status: healthy - Source download looks usable. - Yavira can redirect you to the upstream package for this source. - Health scope: source - Reason: direct_download_ok - Checked at: 2026-04-30T16:55:25.780Z - Expires at: 2026-05-07T16:55:25.780Z - Recommended action: Download for OpenClaw ## Links - [Detail page](https://openagent3.xyz/skills/clarity-clinical) - [Send to Agent page](https://openagent3.xyz/skills/clarity-clinical/agent) - [JSON manifest](https://openagent3.xyz/skills/clarity-clinical/agent.json) - [Markdown brief](https://openagent3.xyz/skills/clarity-clinical/agent.md) - [Download page](https://openagent3.xyz/downloads/clarity-clinical)