# Send Genomics to your agent
Hand the extracted package to your coding agent with a concrete install brief instead of figuring it out manually.
## Fast path
- Download the package from Yavira.
- Extract it into a folder your agent can access.
- Paste one of the prompts below and point your agent at the extracted folder.
## Suggested prompts
### New install

```text
I downloaded a skill package from Yavira. Read SKILL.md from the extracted folder and install it by following the included instructions. Tell me what you changed and call out any manual steps you could not complete.
```
### Upgrade existing

```text
I downloaded an updated skill package from Yavira. Read SKILL.md from the extracted folder, compare it with my current installation, and upgrade it while preserving any custom configuration unless the package docs explicitly say otherwise. Summarize what changed and any follow-up checks I should run.
```
## Machine-readable fields
```json
{
  "schemaVersion": "1.0",
  "item": {
    "slug": "genomics",
    "name": "Genomics",
    "source": "tencent",
    "type": "skill",
    "category": "开发工具",
    "sourceUrl": "https://clawhub.ai/ivangdavila/genomics",
    "canonicalUrl": "https://clawhub.ai/ivangdavila/genomics",
    "targetPlatform": "OpenClaw"
  },
  "install": {
    "downloadUrl": "/downloads/genomics",
    "sourceDownloadUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=genomics",
    "sourcePlatform": "tencent",
    "targetPlatform": "OpenClaw",
    "packageFormat": "ZIP package",
    "primaryDoc": "SKILL.md",
    "includedAssets": [
      "SKILL.md",
      "memory-template.md",
      "setup.md"
    ],
    "downloadMode": "redirect",
    "sourceHealth": {
      "source": "tencent",
      "slug": "genomics",
      "status": "healthy",
      "reason": "direct_download_ok",
      "recommendedAction": "download",
      "checkedAt": "2026-05-03T15:23:24.640Z",
      "expiresAt": "2026-05-10T15:23:24.640Z",
      "httpStatus": 200,
      "finalUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=genomics",
      "contentType": "application/zip",
      "probeMethod": "head",
      "details": {
        "probeUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=genomics",
        "contentDisposition": "attachment; filename=\"genomics-1.0.0.zip\"",
        "redirectLocation": null,
        "bodySnippet": null,
        "slug": "genomics"
      },
      "scope": "item",
      "summary": "Item download looks usable.",
      "detail": "Yavira can redirect you to the upstream package for this item.",
      "primaryActionLabel": "Download for OpenClaw",
      "primaryActionHref": "/downloads/genomics"
    },
    "validation": {
      "installChecklist": [
        "Use the Yavira download entry.",
        "Review SKILL.md after the package is downloaded.",
        "Confirm the extracted package contains the expected setup assets."
      ],
      "postInstallChecks": [
        "Confirm the extracted package includes the expected docs or setup files.",
        "Validate the skill or prompts are available in your target agent workspace.",
        "Capture any manual follow-up steps the agent could not complete."
      ]
    }
  },
  "links": {
    "detailUrl": "https://openagent3.xyz/skills/genomics",
    "downloadUrl": "https://openagent3.xyz/downloads/genomics",
    "agentUrl": "https://openagent3.xyz/skills/genomics/agent",
    "manifestUrl": "https://openagent3.xyz/skills/genomics/agent.json",
    "briefUrl": "https://openagent3.xyz/skills/genomics/agent.md"
  }
}
```
## Documentation

### Setup

On first use, read setup.md for integration guidelines. Ask user consent before creating ~/genomics/ workspace.

### When to Use

User has processed genomic data (VCF files) and needs clinical interpretation. Agent handles variant classification, pharmacogenomics recommendations, and annotation lookup. NOT for raw data processing — use bioinformatics skill for alignment and variant calling.

### Architecture

Memory lives in ~/genomics/. See memory-template.md for structure.

~/genomics/
├── memory.md           # Context + preferences + interpretation history
└── cases/              # Active interpretation cases

### Quick Reference

TopicFileSetup processsetup.mdMemory templatememory-template.md

### 1. Classify Variants Using ACMG Guidelines

Every variant needs systematic classification:

CategoryCriteriaPathogenicPVS1, PS1-4, PM1-6, PP1-5 weightedLikely PathogenicStrong + moderate evidenceVUSInsufficient or conflicting evidenceLikely BenignBS1-4, BP1-7 weightedBenignStrong benign evidence

Never classify without evidence. State "insufficient data" when appropriate.

### 2. Check Population Frequency First

Before clinical interpretation, verify frequency:

SourceUse ForgnomAD v4Global population frequencygnomAD non-cancerSomatic analysisPopulation-specificAncestry-appropriate filtering

MAF >1% in any population = likely benign for rare disease.

### 3. Cross-Reference Multiple Databases

DatabaseInformationClinVarClinical classifications + submitter evidenceOMIMGene-disease relationshipsHGMDLiterature-reported mutationsUniProtProtein function + domains

Single-source interpretation is insufficient. Triangulate evidence.

### 4. Report Pharmacogenomics Actionably

For drug-gene interactions, provide:

Diplotype (e.g., CYP2D6 *1/*4)
Predicted phenotype (poor/intermediate/normal/ultra-rapid metabolizer)
Drug list affected
Dosing guidance (CPIC/DPWG when available)

### 5. Separate Germline from Somatic Context

ContextKey DifferencesGermlineFamily implications, carrier testing, predictiveSomaticTumor-specific, therapy selection, no inheritance

Always state which context you're interpreting.

### 6. Acknowledge Uncertainty

Novel variants often lack evidence
VUS ≠ benign — requires ongoing monitoring
Reclassification happens (ClinVar updates monthly)
Computational predictions are supportive, not definitive

### High-Priority Drug-Gene Pairs (CPIC Level A)

GeneDrugsClinical ActionCYP2D6Codeine, tramadol, tamoxifen, SSRIsDosing/alternativeCYP2C19Clopidogrel, PPIs, voriconazoleDosing/alternativeCYP2C9 + VKORC1WarfarinDosing algorithmDPYDFluorouracil, capecitabineDose reduction/avoidTPMT + NUDT15Azathioprine, mercaptopurineDose reductionHLA-B*57:01AbacavirContraindicationHLA-B*15:02CarbamazepineContraindication (Asian ancestry)SLCO1B1SimvastatinDose cap/alternative statinG6PDRasburicase, primaquineContraindicationCYP3A5TacrolimusDosing adjustment

### Phenotype Interpretation

Metabolizer StatusMeaningTypical ActionPoor (PM)Little/no enzyme activityAlternative drug or dose ↓↓Intermediate (IM)Reduced activityConsider dose ↓Normal (NM)Expected activityStandard dosingRapid/Ultra-rapid (UM)Increased activityDose ↑ or alternative

### Annotation Resources

ResourceURLContentClinVarncbi.nlm.nih.gov/clinvarClinical variant classificationsgnomADgnomad.broadinstitute.orgPopulation frequenciesOMIMomim.orgGene-disease relationshipsPharmGKBpharmgkb.orgDrug-gene annotationsCPICcpicpgx.orgPharmacogenomics guidelinesClinGenclinicalgenome.orgGene-disease validityFranklinfranklin.genoox.comVariant interpretation aidVarSomevarsome.comACMG auto-classification

### Common Interpretation Traps

Ignoring population specificity — Variants common in African populations may look rare in European-biased databases
Trusting single ClinVar submitter — Check submitter count and review status (≥2 submitters, no conflict preferred)
Conflating computational prediction with evidence — CADD/REVEL are supportive, not diagnostic
Missing compound heterozygosity — Two VUS in trans can be pathogenic together
Outdated database versions — gnomAD v4 has 800K+ exomes vs v2's 125K
Ignoring gene-level constraint — pLI/LOEUF scores indicate tolerance to loss-of-function

### External Endpoints

This skill does NOT automatically call external APIs. All database references are for manual lookup:

ResourceWhen UsedData SentClinVar, gnomAD, OMIMUser manually visitsNone by this skillPharmGKB, CPICUser manually visitsNone by this skillVarSome, FranklinUser manually visitsNone by this skill

No automatic network requests. The skill provides URLs and guidance for manual lookup only.

### Security & Privacy

Data that stays local:

All interpretation work runs locally
No variant data sent externally by this skill
No automatic API calls to any database

This skill does NOT:

Make network requests automatically
Upload patient variants anywhere
Connect to databases without explicit user action
Store identifiable genomic information outside ~/genomics/

### Related Skills

Install with clawhub install <slug> if user confirms:

medicine — clinical decision support
biology — molecular mechanisms
chemistry — drug metabolism pathways
health — patient care context

### Feedback

If useful: clawhub star genomics
Stay updated: clawhub sync
## Trust
- Source: tencent
- Verification: Indexed source record
- Publisher: ivangdavila
- Version: 1.0.0
## Source health
- Status: healthy
- Item download looks usable.
- Yavira can redirect you to the upstream package for this item.
- Health scope: item
- Reason: direct_download_ok
- Checked at: 2026-05-03T15:23:24.640Z
- Expires at: 2026-05-10T15:23:24.640Z
- Recommended action: Download for OpenClaw
## Links
- [Detail page](https://openagent3.xyz/skills/genomics)
- [Send to Agent page](https://openagent3.xyz/skills/genomics/agent)
- [JSON manifest](https://openagent3.xyz/skills/genomics/agent.json)
- [Markdown brief](https://openagent3.xyz/skills/genomics/agent.md)
- [Download page](https://openagent3.xyz/downloads/genomics)