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        "label": "New install",
        "body": "I downloaded a skill package from Yavira. Read SKILL.md from the extracted folder and install it by following the included instructions. Then review README.md for any prerequisites, environment setup, or post-install checks. Tell me what you changed and call out any manual steps you could not complete."
      },
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    "sections": [
      {
        "title": "Medical Research Toolkit",
        "body": "Query 14+ biomedical databases for drug repurposing, target discovery, clinical evidence, and literature research — all via a unified MCP endpoint."
      },
      {
        "title": "⚡ 30-Second Start",
        "body": "# Find drugs for myasthenia gravis\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"chembl_find_drugs_by_indication\",\"arguments\":{\"indication\":\"myasthenia gravis\",\"max_results\":10}},\"id\":1}'\n\nThat's it! You now have approved and investigational drugs for the disease."
      },
      {
        "title": "Find Drugs for a Disease",
        "body": "curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"chembl_find_drugs_by_indication\",\"arguments\":{\"indication\":\"myasthenia gravis\",\"max_results\":20}},\"id\":1}'\n\nReturns: Approved + investigational drugs with max phase reached"
      },
      {
        "title": "Find Disease Targets",
        "body": "# First: Find disease ID\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"opentargets_search\",\"arguments\":{\"query\":\"myasthenia gravis\",\"entity_type\":\"disease\"}},\"id\":1}'\n\n# Returns: disease ID (e.g., EFO_0004991)\n# Then: Get targets\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"opentargets_get_associations\",\"arguments\":{\"disease_id\":\"EFO_0004991\",\"size\":20}},\"id\":2}'\n\nReturns: Top disease targets ranked by evidence strength (0-1 score)"
      },
      {
        "title": "Search Literature",
        "body": "curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"pubmed_search_articles\",\"arguments\":{\"diseases\":[\"myasthenia gravis\"],\"keywords\":[\"immunotherapy\"],\"max_results\":20}},\"id\":1}'\n\nReturns: PubMed articles on myasthenia gravis immunotherapy"
      },
      {
        "title": "Find Active Clinical Trials",
        "body": "curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"ctg_search_studies\",\"arguments\":{\"condition\":\"myasthenia gravis\",\"recruitment_status\":\"RECRUITING\",\"max_results\":20}},\"id\":1}'\n\nReturns: Actively recruiting trials for the disease"
      },
      {
        "title": "Check Drug Safety",
        "body": "curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"openfda_search_adverse_events\",\"arguments\":{\"drug_name\":\"eculizumab\",\"limit\":50}},\"id\":1}'\n\nReturns: FDA adverse event reports—check for serious outcomes, death, hospitalization"
      },
      {
        "title": "What You Get",
        "body": "14+ Integrated Databases\n\nDatabaseWhat's InsideUse ForChEMBL2M drugs, bioactivity dataFinding approved/investigational drugsOpenTargetsDisease-target links + evidenceIdentifying therapeutic targetsPubMed35M+ articles + preprintsLiterature review & validationClinicalTrials.gov400K+ active trialsFinding ongoing studiesOpenFDAAdverse events, drug labelsSafety assessmentOMIMGenetic diseases, genes → phenotypesUnderstanding disease geneticsReactomePathways, protein interactionsMechanism understandingUniProtProtein sequences, annotationsProtein propertiesKEGGMetabolic & disease pathwaysSystems-level viewGWAS CatalogGenetic associationsVariant discoveryPathway CommonsIntegrated pathway dataNetwork analysisMyGene.infoGene annotationsID mappingMyVariant.infoVariant effectsVariant interpretation+ more"
      },
      {
        "title": "🧬 Drug Repurposing",
        "body": "Find non-standard-care drugs for rare/complex diseases:\n\nFind disease targets (OpenTargets)\nSearch for drugs targeting those genes (ChEMBL)\nCheck ongoing trials (ClinicalTrials)\nVerify safety (OpenFDA, PubMed)"
      },
      {
        "title": "🔬 Target Discovery",
        "body": "Identify novel therapeutic targets:\n\nFind disease associations (OpenTargets, GWAS)\nGet pathway context (Reactome, KEGG)\nReview literature (PubMed)\nCheck protein properties (UniProt)"
      },
      {
        "title": "📋 Clinical Evidence Review",
        "body": "Compile evidence for a hypothesis:\n\nSearch trials (ClinicalTrials.gov)\nFind literature (PubMed)\nCheck FDA data (OpenFDA)"
      },
      {
        "title": "📊 Literature Mining",
        "body": "Systematically search biomedical research:\n\nPubMed: 35M+ articles searchable by gene, disease, drug, chemical\nPreprints: bioRxiv, medRxiv\nFilter by keywords, date, study type"
      },
      {
        "title": "API Endpoint",
        "body": "Production (No setup needed):\n\nhttps://mcp.cloud.curiloo.com/tools/unified/mcp\n\nAll 14+ databases unified into one endpoint.\n\nRunning Locally:\n\npip install medical-mcps\nmedical-mcps\n# Available at: http://localhost:8000/tools/unified/mcp"
      },
      {
        "title": "Complete References",
        "body": "See detailed guides for each database:\n\nPubMed Guide — Literature search (genes, diseases, keywords)\nClinicalTrials Guide — Find active trials\nChEMBL Guide — Drug-target data & bioactivity\nOpenTargets Guide — Disease-target associations\nOpenFDA Guide — Drug safety & adverse events\nOMIM Guide — Genetic diseases (requires API key)\nOther APIs — Reactome, UniProt, KEGG, GWAS, etc."
      },
      {
        "title": "Workflow Example",
        "body": "Complete Drug Repurposing Pipeline:\n\nSee drug-repurposing-workflow.md for step-by-step example with all 8 steps + curl commands."
      },
      {
        "title": "API Keys",
        "body": "Most APIs are free, no key required. Optional keys for higher rate limits:\n\nDatabaseKey?WhyGet KeyChEMBLNoPublic data(not needed)OpenTargetsNoPublic data(not needed)PubMedNoPublic data(not needed)ClinicalTrialsNoPublic data(not needed)OMIMYesProprietary datahttps://omim.org/apiOpenFDAOptionalHigher rate limitshttps://open.fda.govNCI Clinical TrialsOptionalHigher rate limitshttps://clinicaltrialsapi.cancer.gov"
      },
      {
        "title": "Rate Limits & Caching",
        "body": "No authentication for production endpoint (public)\nRate limits: Generous (~1000+ requests/day per database)\nCaching: Automatic 30-day HTTP caching (RFC 9111)\nCost: $0 (all databases public or researcher-accessible)"
      },
      {
        "title": "Batch Query Loop",
        "body": "# Search multiple targets\nfor gene in CHRNE RAPSN LRP4; do\n  curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n    -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n    -d \"{\\\"jsonrpc\\\":\\\"2.0\\\",\\\"method\\\":\\\"tools/call\\\",\\\"params\\\":{\\\"name\\\":\\\"chembl_find_drugs_by_target\\\",\\\"arguments\\\":{\\\"target_name\\\":\\\"$gene\\\",\\\"max_results\\\":10}},\\\"id\\\":1}\"\n  sleep 1  # Be nice to the API\ndone"
      },
      {
        "title": "ID Conversion",
        "body": "Need to convert IDs between databases?\n\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"nodenorm_get_normalized_nodes\",\"arguments\":{\"curie\":\"HGNC:11998\"}},\"id\":1}'\n\nReturns: Equivalent IDs in NCBI Gene, Uniprot, Ensembl, MyGene, etc."
      },
      {
        "title": "Troubleshooting",
        "body": "No results?\n\nTry alternative terms (gene symbol vs protein name)\nCheck spelling\nUse standardized IDs (gene symbols, disease names)\nSome APIs use specific ID formats (EFO vs MONDO, etc.)\n\nToo many results?\n\nAdd filters (max_results, phase, recruitment status)\nUse limit or size parameters\nCombine with other databases to narrow focus\n\nAPI key errors?\n\nOMIM requires API key — get from https://omim.org/api\nOther databases optional — request key if hitting rate limits"
      },
      {
        "title": "Next Steps",
        "body": "Pick a use case (drug repurposing, target discovery, etc.)\nRead the relevant database guide from References section\nCopy a quick recipe from above\nCustomize parameters for your disease/gene/drug\nScale up — build your full research workflow"
      },
      {
        "title": "Resources",
        "body": "Source Code: https://github.com/pascalwhoop/medical-mcps\nAuthor: Pascal Brockmeyer (@pascalwhoop)\nOrganization: Every Cure (https://www.everycure.org)\nLicense: MIT"
      },
      {
        "title": "Getting Help",
        "body": "Database not working? → Check Troubleshooting\nWant detailed guide? → See Complete References\nNeed a workflow example? → See drug-repurposing-workflow.md\nQuestion about OpenClaw? → See OPENCLAW-USAGE.md"
      }
    ],
    "body": "Medical Research Toolkit\n\nQuery 14+ biomedical databases for drug repurposing, target discovery, clinical evidence, and literature research — all via a unified MCP endpoint.\n\n⚡ 30-Second Start\n# Find drugs for myasthenia gravis\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"chembl_find_drugs_by_indication\",\"arguments\":{\"indication\":\"myasthenia gravis\",\"max_results\":10}},\"id\":1}'\n\n\nThat's it! You now have approved and investigational drugs for the disease.\n\nQuick Recipes\nFind Drugs for a Disease\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"chembl_find_drugs_by_indication\",\"arguments\":{\"indication\":\"myasthenia gravis\",\"max_results\":20}},\"id\":1}'\n\n\nReturns: Approved + investigational drugs with max phase reached\n\nFind Disease Targets\n# First: Find disease ID\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"opentargets_search\",\"arguments\":{\"query\":\"myasthenia gravis\",\"entity_type\":\"disease\"}},\"id\":1}'\n\n# Returns: disease ID (e.g., EFO_0004991)\n# Then: Get targets\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"opentargets_get_associations\",\"arguments\":{\"disease_id\":\"EFO_0004991\",\"size\":20}},\"id\":2}'\n\n\nReturns: Top disease targets ranked by evidence strength (0-1 score)\n\nSearch Literature\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"pubmed_search_articles\",\"arguments\":{\"diseases\":[\"myasthenia gravis\"],\"keywords\":[\"immunotherapy\"],\"max_results\":20}},\"id\":1}'\n\n\nReturns: PubMed articles on myasthenia gravis immunotherapy\n\nFind Active Clinical Trials\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"ctg_search_studies\",\"arguments\":{\"condition\":\"myasthenia gravis\",\"recruitment_status\":\"RECRUITING\",\"max_results\":20}},\"id\":1}'\n\n\nReturns: Actively recruiting trials for the disease\n\nCheck Drug Safety\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"openfda_search_adverse_events\",\"arguments\":{\"drug_name\":\"eculizumab\",\"limit\":50}},\"id\":1}'\n\n\nReturns: FDA adverse event reports—check for serious outcomes, death, hospitalization\n\nWhat You Get\n\n14+ Integrated Databases\n\nDatabase\tWhat's Inside\tUse For\nChEMBL\t2M drugs, bioactivity data\tFinding approved/investigational drugs\nOpenTargets\tDisease-target links + evidence\tIdentifying therapeutic targets\nPubMed\t35M+ articles + preprints\tLiterature review & validation\nClinicalTrials.gov\t400K+ active trials\tFinding ongoing studies\nOpenFDA\tAdverse events, drug labels\tSafety assessment\nOMIM\tGenetic diseases, genes → phenotypes\tUnderstanding disease genetics\nReactome\tPathways, protein interactions\tMechanism understanding\nUniProt\tProtein sequences, annotations\tProtein properties\nKEGG\tMetabolic & disease pathways\tSystems-level view\nGWAS Catalog\tGenetic associations\tVariant discovery\nPathway Commons\tIntegrated pathway data\tNetwork analysis\nMyGene.info\tGene annotations\tID mapping\nMyVariant.info\tVariant effects\tVariant interpretation\n+ more\t\t\nUse Cases\n🧬 Drug Repurposing\n\nFind non-standard-care drugs for rare/complex diseases:\n\nFind disease targets (OpenTargets)\nSearch for drugs targeting those genes (ChEMBL)\nCheck ongoing trials (ClinicalTrials)\nVerify safety (OpenFDA, PubMed)\n🔬 Target Discovery\n\nIdentify novel therapeutic targets:\n\nFind disease associations (OpenTargets, GWAS)\nGet pathway context (Reactome, KEGG)\nReview literature (PubMed)\nCheck protein properties (UniProt)\n📋 Clinical Evidence Review\n\nCompile evidence for a hypothesis:\n\nSearch trials (ClinicalTrials.gov)\nFind literature (PubMed)\nCheck FDA data (OpenFDA)\n📊 Literature Mining\n\nSystematically search biomedical research:\n\nPubMed: 35M+ articles searchable by gene, disease, drug, chemical\nPreprints: bioRxiv, medRxiv\nFilter by keywords, date, study type\nAPI Endpoint\n\nProduction (No setup needed):\n\nhttps://mcp.cloud.curiloo.com/tools/unified/mcp\n\n\nAll 14+ databases unified into one endpoint.\n\nRunning Locally:\n\npip install medical-mcps\nmedical-mcps\n# Available at: http://localhost:8000/tools/unified/mcp\n\nComplete References\n\nSee detailed guides for each database:\n\nPubMed Guide — Literature search (genes, diseases, keywords)\nClinicalTrials Guide — Find active trials\nChEMBL Guide — Drug-target data & bioactivity\nOpenTargets Guide — Disease-target associations\nOpenFDA Guide — Drug safety & adverse events\nOMIM Guide — Genetic diseases (requires API key)\nOther APIs — Reactome, UniProt, KEGG, GWAS, etc.\nWorkflow Example\n\nComplete Drug Repurposing Pipeline:\n\nSee drug-repurposing-workflow.md for step-by-step example with all 8 steps + curl commands.\n\nAPI Keys\n\nMost APIs are free, no key required. Optional keys for higher rate limits:\n\nDatabase\tKey?\tWhy\tGet Key\nChEMBL\tNo\tPublic data\t(not needed)\nOpenTargets\tNo\tPublic data\t(not needed)\nPubMed\tNo\tPublic data\t(not needed)\nClinicalTrials\tNo\tPublic data\t(not needed)\nOMIM\tYes\tProprietary data\thttps://omim.org/api\nOpenFDA\tOptional\tHigher rate limits\thttps://open.fda.gov\nNCI Clinical Trials\tOptional\tHigher rate limits\thttps://clinicaltrialsapi.cancer.gov\nRate Limits & Caching\nNo authentication for production endpoint (public)\nRate limits: Generous (~1000+ requests/day per database)\nCaching: Automatic 30-day HTTP caching (RFC 9111)\nCost: $0 (all databases public or researcher-accessible)\nCommon Patterns\nBatch Query Loop\n# Search multiple targets\nfor gene in CHRNE RAPSN LRP4; do\n  curl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n    -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n    -d \"{\\\"jsonrpc\\\":\\\"2.0\\\",\\\"method\\\":\\\"tools/call\\\",\\\"params\\\":{\\\"name\\\":\\\"chembl_find_drugs_by_target\\\",\\\"arguments\\\":{\\\"target_name\\\":\\\"$gene\\\",\\\"max_results\\\":10}},\\\"id\\\":1}\"\n  sleep 1  # Be nice to the API\ndone\n\nID Conversion\n\nNeed to convert IDs between databases?\n\ncurl -X POST https://mcp.cloud.curiloo.com/tools/unified/mcp \\\n  -H \"Content-Type: application/json\" -H \"Accept: application/json\" \\\n  -d '{\"jsonrpc\":\"2.0\",\"method\":\"tools/call\",\"params\":{\"name\":\"nodenorm_get_normalized_nodes\",\"arguments\":{\"curie\":\"HGNC:11998\"}},\"id\":1}'\n\n\nReturns: Equivalent IDs in NCBI Gene, Uniprot, Ensembl, MyGene, etc.\n\nTroubleshooting\n\nNo results?\n\nTry alternative terms (gene symbol vs protein name)\nCheck spelling\nUse standardized IDs (gene symbols, disease names)\nSome APIs use specific ID formats (EFO vs MONDO, etc.)\n\nToo many results?\n\nAdd filters (max_results, phase, recruitment status)\nUse limit or size parameters\nCombine with other databases to narrow focus\n\nAPI key errors?\n\nOMIM requires API key — get from https://omim.org/api\nOther databases optional — request key if hitting rate limits\nNext Steps\nPick a use case (drug repurposing, target discovery, etc.)\nRead the relevant database guide from References section\nCopy a quick recipe from above\nCustomize parameters for your disease/gene/drug\nScale up — build your full research workflow\nResources\nSource Code: https://github.com/pascalwhoop/medical-mcps\nAuthor: Pascal Brockmeyer (@pascalwhoop)\nOrganization: Every Cure (https://www.everycure.org)\nLicense: MIT\nGetting Help\nDatabase not working? → Check Troubleshooting\nWant detailed guide? → See Complete References\nNeed a workflow example? → See drug-repurposing-workflow.md\nQuestion about OpenClaw? → See OPENCLAW-USAGE.md"
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