# Send Personal Genomics to your agent Use the source page and any available docs to guide the install because the item is currently unstable or timing out. ## Fast path - Open the source page via Review source status. - If you can obtain the package, extract it into a folder your agent can access. - Paste one of the prompts below and point your agent at the source page and extracted files. ## Suggested prompts ### New install ```text I tried to install a skill package from Yavira, but the item is currently unstable or timing out. Inspect the source page and any extracted docs, then tell me what you can confirm and any manual steps still required. Then review README.md for any prerequisites, environment setup, or post-install checks. ``` ### Upgrade existing ```text I tried to upgrade a skill package from Yavira, but the item is currently unstable or timing out. Compare the source page and any extracted docs with my current installation, then summarize what changed and what manual follow-up I still need. Then review README.md for any prerequisites, environment setup, or post-install checks. ``` ## Machine-readable fields ```json { "schemaVersion": "1.0", "item": { "slug": "personal-genomics", "name": "Personal Genomics", "source": "tencent", "type": "skill", "category": "数据分析", "sourceUrl": "https://clawhub.ai/wkyleg/personal-genomics", "canonicalUrl": "https://clawhub.ai/wkyleg/personal-genomics", "targetPlatform": "OpenClaw" }, "install": { "downloadUrl": "/downloads/personal-genomics", "sourceDownloadUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=personal-genomics", "sourcePlatform": "tencent", "targetPlatform": "OpenClaw", "packageFormat": "ZIP package", "primaryDoc": "SKILL.md", "includedAssets": [ "CHANGELOG.md", "README.md", "SECURITY.md", "SKILL.md", "advanced_analysis.py", "analyze_dna.py" ], "downloadMode": "manual_only", "sourceHealth": { "source": "tencent", "slug": "personal-genomics", "status": "unstable", "reason": "timeout", "recommendedAction": "retry_later", "checkedAt": "2026-04-30T00:47:08.861Z", "expiresAt": "2026-04-30T12:47:08.861Z", "httpStatus": null, "finalUrl": null, "contentType": null, "probeMethod": "head", "details": { "probeUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=personal-genomics", "error": "Timed out after 5000ms", "slug": "personal-genomics" }, "scope": "item", "summary": "Item is unstable.", "detail": "This item is timing out or returning errors right now. Review the source page and try again later.", "primaryActionLabel": "Review source status", "primaryActionHref": "https://clawhub.ai/wkyleg/personal-genomics" }, "validation": { "installChecklist": [ "Wait for the source to recover or retry later.", "Review SKILL.md only after the download returns a real package.", "Treat this source as transient until the upstream errors clear." ], "postInstallChecks": [ "Confirm the extracted package includes the expected docs or setup files.", "Validate the skill or prompts are available in your target agent workspace.", "Capture any manual follow-up steps the agent could not complete." ] } }, "links": { "detailUrl": "https://openagent3.xyz/skills/personal-genomics", "downloadUrl": "https://openagent3.xyz/downloads/personal-genomics", "agentUrl": "https://openagent3.xyz/skills/personal-genomics/agent", "manifestUrl": "https://openagent3.xyz/skills/personal-genomics/agent.json", "briefUrl": "https://openagent3.xyz/skills/personal-genomics/agent.md" } } ``` ## Documentation ### Personal Genomics Skill v4.2.0 Comprehensive local DNA analysis with 1600+ markers across 30 categories. Privacy-first genetic analysis for AI agents. ### Quick Start python comprehensive_analysis.py /path/to/dna_file.txt ### Triggers Activate this skill when user mentions: DNA analysis, genetic analysis, genome analysis 23andMe, AncestryDNA, MyHeritage results Pharmacogenomics, drug-gene interactions Medication interactions, drug safety Genetic risk, disease risk, health risk Carrier status, carrier testing VCF file analysis APOE, MTHFR, CYP2D6, BRCA, or other gene names Polygenic risk scores Haplogroups, maternal lineage, paternal lineage Ancestry composition, ethnicity Hereditary cancer, Lynch syndrome Autoimmune genetics, HLA, celiac Pain sensitivity, opioid response Sleep optimization, chronotype, caffeine metabolism Dietary genetics, lactose intolerance, celiac Athletic genetics, sports performance UV sensitivity, skin type, melanoma risk Telomere length, longevity genetics ### Supported Files 23andMe, AncestryDNA, MyHeritage, FTDNA VCF files (whole genome/exome, .vcf or .vcf.gz) Any tab-delimited rsid format ### Output Location ~/dna-analysis/reports/ agent_summary.json - AI-optimized, priority-sorted full_analysis.json - Complete data report.txt - Human-readable genetic_report.pdf - Professional PDF report ### Haplogroup Analysis Mitochondrial DNA (mtDNA) - maternal lineage Y-chromosome - paternal lineage (males only) Migration history context PhyloTree/ISOGG standards ### Ancestry Composition Population comparisons (EUR, AFR, EAS, SAS, AMR) Admixture detection Ancestry informative markers ### Hereditary Cancer Panel BRCA1/BRCA2 comprehensive Lynch syndrome (MLH1, MSH2, MSH6, PMS2) Other genes (APC, TP53, CHEK2, PALB2, ATM) ACMG-style classification ### Autoimmune HLA Celiac (DQ2/DQ8) - can rule out if negative Type 1 Diabetes Ankylosing spondylitis (HLA-B27) Rheumatoid arthritis, lupus, MS ### Pain Sensitivity COMT Val158Met OPRM1 opioid receptor SCN9A pain signaling TRPV1 capsaicin sensitivity Migraine susceptibility ### PDF Reports Professional format Physician-shareable Executive summary Detailed findings Disclaimers included ### Medication Interaction Checker from markers.medication_interactions import check_medication_interactions result = check_medication_interactions( medications=["warfarin", "clopidogrel", "omeprazole"], genotypes=user_genotypes ) # Returns critical/serious/moderate interactions with alternatives Accepts brand or generic names CPIC guidelines integrated PubMed citations included FDA warning flags ### Sleep Optimization Profile from markers.sleep_optimization import generate_sleep_profile profile = generate_sleep_profile(genotypes) # Returns ideal wake/sleep times, coffee cutoff, etc. Chronotype (morning/evening preference) Caffeine metabolism speed Personalized timing recommendations ### Dietary Interaction Matrix from markers.dietary_interactions import analyze_dietary_interactions diet = analyze_dietary_interactions(genotypes) # Returns food-specific guidance Caffeine, alcohol, saturated fat, lactose, gluten APOE-specific diet recommendations Bitter taste perception ### Athletic Performance Profile from markers.athletic_profile import calculate_athletic_profile profile = calculate_athletic_profile(genotypes) # Returns power/endurance type, recovery profile, injury risk Sport suitability scoring Training recommendations Injury prevention guidance ### UV Sensitivity Calculator from markers.uv_sensitivity import generate_uv_sensitivity_report uv = generate_uv_sensitivity_report(genotypes) # Returns skin type, SPF recommendation, melanoma risk Fitzpatrick skin type estimation Vitamin D synthesis capacity Melanoma risk factors ### Natural Language Explanations from markers.explanations import generate_plain_english_explanation explanation = generate_plain_english_explanation( rsid="rs3892097", gene="CYP2D6", genotype="GA", trait="Drug metabolism", finding="Poor metabolizer carrier" ) Plain-English summaries Research variant flagging PubMed links ### Telomere & Longevity from markers.advanced_genetics import estimate_telomere_length telomere = estimate_telomere_length(genotypes) # Returns relative estimate with appropriate caveats TERT, TERC, OBFC1 variants Longevity associations (FOXO3, APOE) ### Data Quality Call rate analysis Platform detection Confidence scoring Quality warnings ### Export Formats Genetic counselor clinical export Apple Health compatible API-ready JSON Integration hooks ### Marker Categories (21 total) Pharmacogenomics (159) - Drug metabolism Polygenic Risk Scores (277) - Disease risk Carrier Status (181) - Recessive carriers Health Risks (233) - Disease susceptibility Traits (163) - Physical/behavioral Haplogroups (44) - Lineage markers Ancestry (124) - Population informative Hereditary Cancer (41) - BRCA, Lynch, etc. Autoimmune HLA (31) - HLA associations Pain Sensitivity (20) - Pain/opioid response Rare Diseases (29) - Rare conditions Mental Health (25) - Psychiatric genetics Dermatology (37) - Skin and hair Vision & Hearing (33) - Sensory genetics Fertility (31) - Reproductive health Nutrition (34) - Nutrigenomics Fitness (30) - Athletic performance Neurogenetics (28) - Cognition/behavior Longevity (30) - Aging markers Immunity (43) - HLA and immune Ancestry AIMs (24) - Admixture markers ### Agent Integration The agent_summary.json provides: { "critical_alerts": [], "high_priority": [], "medium_priority": [], "pharmacogenomics_alerts": [], "apoe_status": {}, "polygenic_risk_scores": {}, "haplogroups": { "mtDNA": {"haplogroup": "H", "lineage": "maternal"}, "Y_DNA": {"haplogroup": "R1b", "lineage": "paternal"} }, "ancestry": { "composition": {}, "admixture": {} }, "hereditary_cancer": {}, "autoimmune_risk": {}, "pain_sensitivity": {}, "lifestyle_recommendations": { "diet": [], "exercise": [], "supplements": [], "avoid": [] }, "drug_interaction_matrix": {}, "data_quality": {} } ### Pharmacogenomics DPYD variants - 5-FU/capecitabine FATAL toxicity risk HLA-B*5701 - Abacavir hypersensitivity HLA-B*1502 - Carbamazepine SJS (certain populations) MT-RNR1 - Aminoglycoside-induced deafness ### Hereditary Cancer BRCA1/BRCA2 pathogenic - Breast/ovarian cancer syndrome Lynch syndrome genes - Colorectal/endometrial cancer TP53 pathogenic - Li-Fraumeni syndrome (multi-cancer) ### Disease Risk APOE ε4/ε4 - ~12x Alzheimer's risk Factor V Leiden - Thrombosis risk, contraceptive implications HLA-B27 - Ankylosing spondylitis susceptibility (OR ~70) ### Carrier Status CFTR - Cystic fibrosis (1 in 25 Europeans) HBB - Sickle cell (1 in 12 African Americans) HEXA - Tay-Sachs (1 in 30 Ashkenazi Jews) ### Basic Analysis from comprehensive_analysis import main main() # Uses command line args ### Haplogroup Analysis from markers.haplogroups import analyze_haplogroups result = analyze_haplogroups(genotypes) print(result["mtDNA"]["haplogroup"]) # e.g., "H" ### Ancestry from markers.ancestry_composition import get_ancestry_summary ancestry = get_ancestry_summary(genotypes) ### Cancer Panel from markers.cancer_panel import analyze_cancer_panel cancer = analyze_cancer_panel(genotypes) if cancer["pathogenic_variants"]: print("ALERT: Pathogenic variants detected") ### Generate PDF from pdf_report import generate_pdf_report pdf_path = generate_pdf_report(analysis_results) ### Export for Genetic Counselor from exports import generate_genetic_counselor_export clinical = generate_genetic_counselor_export(results, "clinical.json") ### Privacy All analysis runs locally Zero network requests No data leaves the machine ### Limitations Consumer arrays miss rare variants (~0.1% of genome) Results are probabilistic, not deterministic Not a medical diagnosis Most conditions 50-80% non-genetic Consult healthcare providers for medical decisions Negative hereditary cancer result does NOT rule out cancer syndrome Haplogroup resolution limited without WGS ### When to Recommend Genetic Counseling Any pathogenic hereditary cancer variant APOE ε4/ε4 genotype Multiple critical pharmacogenomic findings Carrier status with reproduction implications High-risk autoimmune HLA types with symptoms Results causing significant user distress ## Trust - Source: tencent - Verification: Indexed source record - Publisher: wkyleg - Version: 4.2.0 ## Source health - Status: unstable - Item is unstable. - This item is timing out or returning errors right now. Review the source page and try again later. - Health scope: item - Reason: timeout - Checked at: 2026-04-30T00:47:08.861Z - Expires at: 2026-04-30T12:47:08.861Z - Recommended action: Review source status ## Links - [Detail page](https://openagent3.xyz/skills/personal-genomics) - [Send to Agent page](https://openagent3.xyz/skills/personal-genomics/agent) - [JSON manifest](https://openagent3.xyz/skills/personal-genomics/agent.json) - [Markdown brief](https://openagent3.xyz/skills/personal-genomics/agent.md) - [Download page](https://openagent3.xyz/downloads/personal-genomics)