# Send Refua to your agent Hand the extracted package to your coding agent with a concrete install brief instead of figuring it out manually. ## Fast path - Download the package from Yavira. - Extract it into a folder your agent can access. - Paste one of the prompts below and point your agent at the extracted folder. ## Suggested prompts ### New install ```text I downloaded a skill package from Yavira. Read SKILL.md from the extracted folder and install it by following the included instructions. Tell me what you changed and call out any manual steps you could not complete. ``` ### Upgrade existing ```text I downloaded an updated skill package from Yavira. Read SKILL.md from the extracted folder, compare it with my current installation, and upgrade it while preserving any custom configuration unless the package docs explicitly say otherwise. Summarize what changed and any follow-up checks I should run. ``` ## Machine-readable fields ```json { "schemaVersion": "1.0", "item": { "slug": "refua", "name": "Refua", "source": "tencent", "type": "skill", "category": "开发工具", "sourceUrl": "https://clawhub.ai/jbenjoseph/refua", "canonicalUrl": "https://clawhub.ai/jbenjoseph/refua", "targetPlatform": "OpenClaw" }, "install": { "downloadUrl": "/downloads/refua", "sourceDownloadUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=refua", "sourcePlatform": "tencent", "targetPlatform": "OpenClaw", "packageFormat": "ZIP package", "primaryDoc": "SKILL.md", "includedAssets": [ "SKILL.md" ], "downloadMode": "redirect", "sourceHealth": { "source": "tencent", "slug": "refua", "status": "healthy", "reason": "direct_download_ok", "recommendedAction": "download", "checkedAt": "2026-05-08T02:01:21.113Z", "expiresAt": "2026-05-15T02:01:21.113Z", "httpStatus": 200, "finalUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=refua", "contentType": "application/zip", "probeMethod": "head", "details": { "probeUrl": "https://wry-manatee-359.convex.site/api/v1/download?slug=refua", "contentDisposition": "attachment; filename=\"refua-0.4.1.zip\"", "redirectLocation": null, "bodySnippet": null, "slug": "refua" }, "scope": "item", "summary": "Item download looks usable.", "detail": "Yavira can redirect you to the upstream package for this item.", "primaryActionLabel": "Download for OpenClaw", "primaryActionHref": "/downloads/refua" }, "validation": { "installChecklist": [ "Use the Yavira download entry.", "Review SKILL.md after the package is downloaded.", "Confirm the extracted package contains the expected setup assets." ], "postInstallChecks": [ "Confirm the extracted package includes the expected docs or setup files.", "Validate the skill or prompts are available in your target agent workspace.", "Capture any manual follow-up steps the agent could not complete." ] } }, "links": { "detailUrl": "https://openagent3.xyz/skills/refua", "downloadUrl": "https://openagent3.xyz/downloads/refua", "agentUrl": "https://openagent3.xyz/skills/refua/agent", "manifestUrl": "https://openagent3.xyz/skills/refua/agent.json", "briefUrl": "https://openagent3.xyz/skills/refua/agent.md" } } ``` ## Documentation ### Summary Refua is used in drug discovery to computationally fold and score biomolecular complexes (e.g., protein–ligand/protein–protein) and optionally profile ADMET, helping prioritize which molecules to synthesize and test first in a drug discovery pipeline. This skill runs and connects to the refua-mcp MCP server, which exposes Refua’s “unified Complex API” as MCP tools for: Boltz2 complex folding (+ optional affinity evaluation) BoltzGen design workflows Optional ADMET profiling (when installed) Clawdbot supports MCP natively, so the only requirement is running this MCP server and calling its tools. (github.com) ### When to use Use this skill when you need to: Fold a protein–ligand, protein–protein, or (fold-only) DNA/RNA complex Estimate binding affinity for a specified binder within a complex spec Run ADMET predictions for one or more SMILES ligands (if enabled) Execute GPU/CPU-heavy Refua workflows via MCP tool calls Do NOT use this skill when: The task is a simple deterministic calculation (prefer a non-ML tool) The user expects you to invent sequences/SMILES (request inputs instead) The user requests unsafe wet-lab or clinical guidance ### 1) Install Refua + refua-mcp Install Refua (CPU or CUDA), then install the MCP server package: (github.com) GPU support: pip install refua[cuda] CPU-only: pip install refua MCP server: pip install refua-mcp ### 2) Optional: enable ADMET ADMET tool support is optional and requires an extra: (github.com) pip install refua[admet] ### 3) Download model/assets Boltz2 and BoltzGen require model/molecule assets. Refua can download them automatically: (github.com) python -c "from refua import download_assets; download_assets()" Default asset locations + overrides: (github.com) Boltz2 uses ~/.boltz by default Override via tool option boltz.cache_dir if needed BoltzGen uses a bundled HF artifact by default Override via tool option boltzgen.mol_dir if needed ### Running the MCP server Start the server using the module entrypoint: (github.com) python3 -m refua_mcp.server ## Trust - Source: tencent - Verification: Indexed source record - Publisher: jbenjoseph - Version: 0.4.1 ## Source health - Status: healthy - Item download looks usable. - Yavira can redirect you to the upstream package for this item. - Health scope: item - Reason: direct_download_ok - Checked at: 2026-05-08T02:01:21.113Z - Expires at: 2026-05-15T02:01:21.113Z - Recommended action: Download for OpenClaw ## Links - [Detail page](https://openagent3.xyz/skills/refua) - [Send to Agent page](https://openagent3.xyz/skills/refua/agent) - [JSON manifest](https://openagent3.xyz/skills/refua/agent.json) - [Markdown brief](https://openagent3.xyz/skills/refua/agent.md) - [Download page](https://openagent3.xyz/downloads/refua)