Requirements
- Target platform
- OpenClaw
- Install method
- Manual import
- Extraction
- Extract archive
- Prerequisites
- OpenClaw
- Primary doc
- SKILL.md
Tencent SkillHub · Developer Tools
Refua
Fold and score biomolecular complexes and optionally profile ADMET to prioritize molecules in drug discovery pipelines via the refua-mcp server.
skill openclawclawhub Free
Fold and score biomolecular complexes and optionally profile ADMET to prioritize molecules in drug discovery pipelines via the refua-mcp server.
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Install for OpenClaw
Quick setup
- Download the package from Yavira.
- Extract the archive and review SKILL.md first.
- Import or place the package into your OpenClaw setup.
Package facts
- Download mode
- Yavira redirect
- Package format
- ZIP package
- Source platform
- Tencent SkillHub
- What's included
- SKILL.md
Validation
- Use the Yavira download entry.
- Review SKILL.md after the package is downloaded.
- Confirm the extracted package contains the expected setup assets.
Install with your agent
Agent handoff
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- Download the package from Yavira.
- Extract it into a folder your agent can access.
- Paste one of the prompts below and point your agent at the extracted folder.
New install
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Trust & source
Release facts
- Source
- Tencent SkillHub
- Verification
- Indexed source record
- Version
- 0.4.1
Provenance
- Publisher
- jbenjoseph
- Source page
- View original listing
- Canonical URL
- Open canonical page
Documentation
Summary
Refua is used in drug discovery to computationally fold and score biomolecular complexes (e.g., protein–ligand/protein–protein) and optionally profile ADMET, helping prioritize which molecules to synthesize and test first in a drug discovery pipeline. This skill runs and connects to the refua-mcp MCP server, which exposes Refua’s “unified Complex API” as MCP tools for: Boltz2 complex folding (+ optional affinity evaluation) BoltzGen design workflows Optional ADMET profiling (when installed) Clawdbot supports MCP natively, so the only requirement is running this MCP server and calling its tools. (github.com)
When to use
Use this skill when you need to: Fold a protein–ligand, protein–protein, or (fold-only) DNA/RNA complex Estimate binding affinity for a specified binder within a complex spec Run ADMET predictions for one or more SMILES ligands (if enabled) Execute GPU/CPU-heavy Refua workflows via MCP tool calls Do NOT use this skill when: The task is a simple deterministic calculation (prefer a non-ML tool) The user expects you to invent sequences/SMILES (request inputs instead) The user requests unsafe wet-lab or clinical guidance
1) Install Refua + refua-mcp
Install Refua (CPU or CUDA), then install the MCP server package: (github.com) GPU support: pip install refua[cuda] CPU-only: pip install refua MCP server: pip install refua-mcp
2) Optional: enable ADMET
ADMET tool support is optional and requires an extra: (github.com) pip install refua[admet]
3) Download model/assets
Boltz2 and BoltzGen require model/molecule assets. Refua can download them automatically: (github.com) python -c "from refua import download_assets; download_assets()" Default asset locations + overrides: (github.com) Boltz2 uses ~/.boltz by default Override via tool option boltz.cache_dir if needed BoltzGen uses a bundled HF artifact by default Override via tool option boltzgen.mol_dir if needed
Running the MCP server
Start the server using the module entrypoint: (github.com) python3 -m refua_mcp.server
Category context
Code helpers, APIs, CLIs, browser automation, testing, and developer operations.
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Package contents
Included in package
1 Docs
- SKILL.md